BDBM14722 1-N-[5-Sulfamoyl-1,3,4-thiadiazol-2-yl-(aminosulfonyl-4-phenyl)]-2,6-dimethyl-4-phenylpyridinium perchlorate::2,6-dimethyl-4-phenyl-1-{4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-1-pyridin-1-ylium perchlorate::Sulfonamide, 8::pyridinium-containing sulfonamide analog 14e

SMILES Cc1cc(cc(C)[n+]1-c1ccc(cc1)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O)-c1ccccc1

InChI Key InChIKey=UQVQBJWQKAPUBT-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 14722   

TargetCarbonic anhydrase 2(Human)
Canadian Institutes of Health Research

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  0.200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Canadian Institutes of Health Research

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  0.200nM ΔG°:  -13.0kcal/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Canadian Institutes of Health Research

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  2nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Canadian Institutes of Health Research

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Canadian Institutes of Health Research

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  3nM ΔG°:  -11.6kcal/molepH: 7.5 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Canadian Institutes of Health Research

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  3nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Canadian Institutes of Health Research

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  6nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed