BDBM147174 US8957083, 18

SMILES CN1C(=O)CC2(N=C1N)c1cc(ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1)-c1cccnc1F

InChI Key InChIKey=OOXSJDJYRJXFDJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 147174   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM147174(US8957083, 18)
Affinity DataIC50: 2.40nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2015
Entry Details
Go to US Patent