BDBM147154 US8957083, 30::US8957083, 32

SMILES CC#Cc1cncc(c1)-c1ccc2Oc3c(F)cc(cc3[C@@]3(N=C(N)N(C)C3=O)c2c1)C1=CCOCC1

InChI Key InChIKey=LFHRVTJUXIOETI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 147154   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM147154(US8957083, 32 | US8957083, 30)
Affinity DataIC50: 0.900nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM147154(US8957083, 32 | US8957083, 30)
Affinity DataIC50: 0.5nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2015
Entry Details
Go to US Patent