BDBM14635 1-[5-chloro-4-(4-methylpiperazin-1-yl)-2-(oxolan-3-yloxy)phenyl]-3-(5-cyanopyrazin-2-yl)urea::N-pyrazinylurea Analog 22a

SMILES CN1CCN(CC1)c1cc(OC2CCOC2)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl

InChI Key InChIKey=WGZPKNGTPHFTLZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14635   

TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

LigandPNGBDBM14635(1-[5-chloro-4-(4-methylpiperazin-1-yl)-2-(oxolan-3...)
Affinity DataIC50: 66nMAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2007
Entry Details Article
PubMed