BDBM145912 US8957064, 45.1

SMILES CNc1c(-c2ccccc2)c(nc2nc(C)nn12)-c1ccc(CN2CC(C2)c2n[nH]c(n2)-c2cccc(C)n2)cc1

InChI Key InChIKey=INERYAOKFWMZAQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145912   

TargetRAC-beta serine/threonine-protein kinase(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM145912(US8957064, 45.1)
Affinity DataIC50: 21nMpH: 7.5Assay Description:Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM145912(US8957064, 45.1)
Affinity DataIC50: 11nMpH: 7.5Assay Description:Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
Go to US Patent