BDBM14498 CHEMBL75084::N-[(4-carbamimidoylphenyl)methyl]-2-{5-chloro-2-oxo-6-phenyl-3-[(2-phenylethyl)amino]-1,2-dihydropyrazin-1-yl}acetamide::Pyrazinone Analog 24a

SMILES NC(=N)c1ccc(CNC(=O)Cn2c(c(Cl)nc(NCCc3ccccc3)c2=O)-c2ccccc2)cc1

InChI Key InChIKey=DWXVAXFBBBGUFA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14498   

TargetCoagulation factor VII(Human)
Pharmacia

LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 630nMpH: 8.0 T: 2°CAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 160nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 630nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human thrombin using H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed