BDBM14454 1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine::1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}piperidin-1-yl)-2-(pyridin-4-yl)ethan-1-one::CHEMBL289404::SCH 44342

SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1

InChI Key InChIKey=CIJDLHMXXOJTEJ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14454   

LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 250nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 1.14E+5nMAssay Description:Compound was tested for the inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 250nMAssay Description:Compound was tested for the inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 250nMAssay Description:Inhibitory activity against recombinant human farnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 250nMAssay Description:In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of Ras processing in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 250nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of [3H]farnesyl pyrophosphate binding to human farnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 250nMAssay Description:Activity against rat brain FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 1.14E+5nMAssay Description:Activity against Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14454(1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentad...)
Affinity DataIC50: 250nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed