BDBM14452 4-[(5-{[5-(naphthalen-1-yl)-1H-indol-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile::indole analog 4c

SMILES N#Cc1ccc(Cn2cncc2Cn2ccc3cc(ccc23)-c2cccc3ccccc23)cc1

InChI Key InChIKey=GMRZSXNEOIVFAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14452   

LigandPNGBDBM14452(4-[(5-{[5-(naphthalen-1-yl)-1H-indol-1-yl]methyl}-...)
Affinity DataIC50: 0.930nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14452(4-[(5-{[5-(naphthalen-1-yl)-1H-indol-1-yl]methyl}-...)
Affinity DataIC50: 270nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed