BDBM14451 1-{[1-(2H-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl}-4-(naphthalen-1-yl)-1H-pyrrole-3-carbonitrile::pyrrole analog 4b

SMILES N#Cc1cn(Cc2cncn2Cc2ccc3OCOc3c2)cc1-c1cccc2ccccc12

InChI Key InChIKey=SKJCGFAZESXJPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14451   

LigandPNGBDBM14451(1-{[1-(2H-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-...)
Affinity DataIC50: 6.10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14451(1-{[1-(2H-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-...)
Affinity DataIC50: 520nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed