BDBM14444 2-quinolone analog 3c::4-[(1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl]methyl}-1H-imidazol-5-yl)(hydroxy)methyl]benzonitrile

SMILES Cn1c2ccc(Cn3cncc3C(O)c3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1

InChI Key InChIKey=AABNDRWQEYTFGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14444   

LigandPNGBDBM14444(4-[(1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihy...)
Affinity DataIC50: 44nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14444(4-[(1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed