BDBM14443 (1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl]methyl}-1H-imidazol-5-yl)(4-cyanophenyl)methyl acetate::2-quinolone analog 3b

SMILES CC(=O)OC(c1cncn1Cc1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1)c1ccc(cc1)C#N

InChI Key InChIKey=AEABDQQUYLQDMM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14443   

LigandPNGBDBM14443((1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydro...)
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14443((1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydro...)
Affinity DataIC50: 1.00E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed