BDBM14440 4-[(1-{[5-(3-chlorophenyl)-8-methyl-7-oxo-7,8-dihydro-1,8-naphthyridin-3-yl]methyl}-1H-imidazol-5-yl)methyl]benzonitrile::naphthyridone 3d

SMILES Cn1c2ncc(Cn3cncc3Cc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1

InChI Key InChIKey=FJDHSLHUXADWNR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14440   

LigandPNGBDBM14440(4-[(1-{[5-(3-chlorophenyl)-8-methyl-7-oxo-7,8-dihy...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14440(4-[(1-{[5-(3-chlorophenyl)-8-methyl-7-oxo-7,8-dihy...)
Affinity DataIC50: 4.00E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed