BDBM14436 2-quinolone analog 2b::4-[(5-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl]carbonyl}-1H-imidazol-1-yl)methyl]benzonitrile

SMILES Cn1c2ccc(cc2c(cc1=O)-c1cccc(Cl)c1)C(=O)c1cncn1Cc1ccc(cc1)C#N

InChI Key InChIKey=FHBGLPFCGSFLLW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14436   

LigandPNGBDBM14436(4-[(5-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihy...)
Affinity DataIC50: 29nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14436(4-[(5-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed