BDBM144279 US8969333, CI-amidine

SMILES NC(=O)[C@H](CCCNC(=N)CCl)NC(=O)c1ccccc1

InChI Key InChIKey=BPWATVWOHQZVRP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 144279   

TargetProtein-arginine deiminase type-6(Human)
The Penn State Research Foundation

US Patent
LigandPNGBDBM144279(US8969333, CI-amidine)
Affinity DataIC50: 1.25E+4nMT: 2°CAssay Description:The inhibition efficacy of PAD4 inhibitors were determined by colorimetric measurement of citrulline generated by PAD4 catalyzed citrullination of BA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Zhejiang Ocean University

Curated by ChEMBL
LigandPNGBDBM144279(US8969333, CI-amidine)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of PDE4 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM144279(US8969333, CI-amidine)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of N-terminal full length recombinant human PAD4 expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed