BDBM14416 5-(5-Acetyl-2-propoxy-3-pyridinyl)-2-(1-methyl-3-azetidinyl)-3-propyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-(5-acetyl-2-propoxypyridin-3-yl)-2-(1-methylazetidin-3-yl)-3-propyl-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 46

SMILES CCCOc1ncc(cc1-c1nc2c(CCC)n(nc2c(=O)[nH]1)C1CN(C)C1)C(C)=O

InChI Key InChIKey=PQMBIRFSGDWBOE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14416   

LigandPNGBDBM14416(5-(5-acetyl-2-propoxypyridin-3-yl)-2-(1-methylazet...)
Affinity DataIC50: 14.7nMAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed