BDBM14382 4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl)-3H-purin-8-yl]-2-methyl-propoxy}-benzamide Fumarate::V11294 Analogue 5r

SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(cc2)C(N)=O)cc1OC1CCCC1

InChI Key InChIKey=DYMRKAXKZNLFOP-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14382   

LigandPNGBDBM14382(4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...)
Affinity DataKi:  4.90nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14382(4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...)
Affinity DataKi:  7.60nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14382(4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...)
Affinity DataKi:  8nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14382(4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...)
Affinity DataKi:  155nM ΔG°:  -9.19kcal/molepH: 8.0 T: 2°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14382(4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...)
Affinity DataKi:  312nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed