BDBM143712 US9682961, 1

SMILES O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4nc[nH]c4c3)nc12

InChI Key InChIKey=FYWRWBSYRGSWIQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 143712   

TargetCatenin beta-1/Protein Wnt-3a(Human)
Carna Biosciences

US Patent
LigandPNGBDBM143712(US9682961, 1)
Affinity DataIC50: 300nMAssay Description:Using ONE-Glo Luciferase Assay System (Promega Corporation, No. E6110), the luciferase activity of the cells in the wells was measured by a microplat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM143712(US9682961, 1)
Affinity DataIC50: 21nMAssay Description:Inhibition of TNIK (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM143712(US9682961, 1)
Affinity DataIC50: 17nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM143712(US9682961, 1)
Affinity DataIC50: 35nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM143712(US9682961, 1)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant TNIK (1 to 367 residues) using RLGRDKYKTLRQIRQ as substrate incubated for 40 mins in presence of Mg/ATP mix by [gamma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed