BDBM143468 US8969341, 109

SMILES CCn1cc(cc(Cl)c1=O)N1C(c2c(nn(c2C(C)C)-c2ccccc2OC)C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=FZVOKZVDSZAECZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 143468   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM143468(US8969341, 109)
Affinity DataIC50: 2.20nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
Go to US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandPNGBDBM143468(US8969341, 109)
Affinity DataIC50: 1.91E+3nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM143468(US8969341, 109)
Affinity DataIC50: 0.377nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
Go to US Patent