BDBM142234 US8933098, 1::US8933099, 1

SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(O)CC1

InChI Key InChIKey=WOJKYHBOHSQZDW-UHFFFAOYSA-N

Data  8 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 142234   

TargetCytochrome P450 2C9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 123nMAssay Description:Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against rat EP4 assessed as inhibition of PGE2-stimulated production of cAMPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 5.60nMAssay Description:Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataIC50: 9.80nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi:  58nMAssay Description:Binding affinity to human EP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi:  76nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing human EP1 (Genbank accession number AY275470) or EP4 (Genbank ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP3 subtype(Human)
Eli Lilly

US Patent
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi: >1.40E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing human EP1 (Genbank accession number AY275470) or EP4 (Genbank ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP3 subtype(Human)
Eli Lilly

US Patent
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi: >1.40E+4nMAssay Description:Binding affinity to human EP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Eli Lilly

US Patent
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi: >1.75E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing human EP1 (Genbank accession number AY275470) or EP4 (Genbank ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP1 subtype(Human)
Eli Lilly

US Patent
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi: >1.75E+4nMAssay Description:Binding affinity to human EP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi: >1.89E+4nMAssay Description:Binding affinity to human EP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933099, 1 | US8933098, 1)
Affinity DataKi: >1.89E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing human EP1 (Genbank accession number AY275470) or EP4 (Genbank ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2015
Entry Details
Go to US Patent