BDBM14195 7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine::pyrrolopyrimidine 18

SMILES COc1cccc(c1)-n1ccc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12

InChI Key InChIKey=RTOLRZJVJBIABS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14195   

TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14195(7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50: 18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14195(7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50: 340nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed