BDBM14156 3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-methylbenzamide::APC-10484::CHEMBL61327

SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N

InChI Key InChIKey=LTXLJGIDFWWEQI-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14156   

TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  77nM ΔG°:  -9.60kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  150nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  150nMAssay Description:Inhibition of urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  280nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  280nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  290nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  360nMAssay Description:Activation of plasminogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  410nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  440nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  4.40E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetPlasminogen(Human)
Axys Pharmaceutical

LigandPNGBDBM14156(CHEMBL61327 | 3-bromo-N-(4-carbamimidoylphenyl)-2-...)
Affinity DataKi:  4.40E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed