BDBM141507 US8921370, 161::US9656975, 161

SMILES Cc1cncc(n1)C(=O)N[C@@]12CC[C@@](C1)(CCC2)NC(=O)c1cccc(F)c1

InChI Key InChIKey=JJSGQCLDNBSOPP-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 141507   

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141507(US8921370, 161 | US9656975, 161)
Affinity DataIC50: 134nMpH: 7.4 T: 2°CAssay Description:The cDNA for rat metabotropic glutamate receptor 5 (rmGluR5) and the cDNA for human metabotropic glutamate receptor 5 (rmGluR5) were generous gifts f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141507(US8921370, 161 | US9656975, 161)
Affinity DataIC50: 134nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141507(US8921370, 161 | US9656975, 161)
Affinity DataKi:  1.20E+3nM ΔG°:  -8.07kcal/molepH: 7.4 T: 2°CAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol. Pharmacol., 2003, 64, 731-740] with slight modifications, including that a r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, kainate 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM141507(US8921370, 161 | US9656975, 161)
Affinity DataKi:  1.20E+3nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
Go to US Patent