BDBM141459 US8921368, 123

SMILES CC1(CCCC1Nc1c(cnn2cc(cc12)-c1ccccc1)C(N)=O)C#N

InChI Key InChIKey=ADGZEMSWFJNDIG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141459   

TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM141459(US8921368, 123)
Affinity DataIC50: 0.200nMpH: 8.0 T: 2°CAssay Description:Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM141459(US8921368, 123)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
Go to US Patent