BDBM141421 US10668051, Compound Example 78::US8921364, 78

SMILES Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F

InChI Key InChIKey=KFLALJIMRGRRSE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141421   

TargetEF-hand calcium-binding domain-containing protein 4B(Human)
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM141421(US8921364, 78 | US10668051, Compound Example 78)
Affinity DataIC50: 34.1nMT: 2°CAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
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TargetCalcium release-activated calcium channel protein 1(Human)
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM141421(US8921364, 78 | US10668051, Compound Example 78)
Affinity DataIC50: 34.1nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent