BDBM14014 (5S)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19.6.2.1^{2,5}.1^{15,19}.0^{9,13}.0^{24,28}]hentriaconta-1(27),9,11,15,17,19(30),21(29),22,24(28),25-decaene-18-carbonitrile::CHEMBL55826::Macrocyclic 3-Aminopyrrolidinone analog 66

SMILES O=C1[C@@H]2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5CCN2)ccc4C#N)cc13

InChI Key InChIKey=OBXLXUGOZZWQOW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14014   

LigandPNGBDBM14014(CHEMBL55826 | (5S)-31-oxo-20-oxa-2,6,11,13-tetraaz...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14014(CHEMBL55826 | (5S)-31-oxo-20-oxa-2,6,11,13-tetraaz...)
Affinity DataIC50: 5.5nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14014(CHEMBL55826 | (5S)-31-oxo-20-oxa-2,6,11,13-tetraaz...)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
LigandPNGBDBM14014(CHEMBL55826 | (5S)-31-oxo-20-oxa-2,6,11,13-tetraaz...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed