BDBM14007 (6R)-24-bromo-27-oxo-20-oxa-3,7,11,13-tetraazapentacyclo[19.3.1.1^{3,6}.1^{15,19}.0^{9,13}]heptacosa-1(24),9,11,15(26),16,18,21(25),22-octaene-18-carbonitrile::CHEMBL524997::Macrocyclic 3-Aminopyrrolidinone analog 37

SMILES Brc1ccc2Oc3cc(Cn4cncc4CN[C@@H]4CCN(Cc1c2)C4=O)ccc3C#N

InChI Key InChIKey=OUQYWOOMZNKZCC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14007   

LigandPNGBDBM14007(CHEMBL524997 | (6R)-24-bromo-27-oxo-20-oxa-3,7,11,...)
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14007(CHEMBL524997 | (6R)-24-bromo-27-oxo-20-oxa-3,7,11,...)
Affinity DataIC50: 9.20E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14007(CHEMBL524997 | (6R)-24-bromo-27-oxo-20-oxa-3,7,11,...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed