BDBM14003 (20R)-17-(3-Chlorophenyl)-19,20,21,22-tetrahydro-19-oxo-5H,18H-18,20-ethano-6,10:12,16-dimetheno-16H-imidazo[3,4-h][1,8,11,14]oxatriazacycloeicosine-9-carbonitrile::(6R)-2-(3-chlorophenyl)-27-oxo-20-oxa-3,7,11,13-tetraazapentacyclo[19.3.1.1^{3,6}.1^{15,19}.0^{9,13}]heptacosa-1(24),9,11,15(26),16,18,21(25),22-octaene-18-carbonitrile::Diastereomer A ( (R,R) or (S,R))::Diastereomer B ( (S,R) or (R,R))::Macrocyclic 3-Aminopyrrolidinone analog 27A::Macrocyclic 3-Aminopyrrolidinone analog 27B

SMILES Clc1cccc(c1)C1N2CC[C@@H](NCc3cncn3Cc3ccc(C#N)c(Oc4cccc1c4)c3)C2=O

InChI Key InChIKey=MVPXMHNFAQUXRM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14003   

LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 25nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 2.5nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 820nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 7.00E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 82nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 82nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed