BDBM140019 US8901310, Comparator I

SMILES Cc1ncccc1NC(=O)c1ccc2c(C=C[C@@H]3C[C@](O)(CC[C@@]23Cc2ccccc2)C(F)(F)F)c1

InChI Key InChIKey=UHIXENGVNOWISA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140019   

TargetInterleukin-6(Human)
Pfizer

US Patent
LigandPNGBDBM140019(US8901310, Comparator I)
Affinity DataIC50: 2.80nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2015
Entry Details
Go to US Patent

TargetGlucocorticoid receptor(Human)
Pfizer

US Patent
LigandPNGBDBM140019(US8901310, Comparator I)
Affinity DataIC50: 9.12nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2015
Entry Details
Go to US Patent