BDBM140011 US8901310, Comparator A

SMILES Cc1ncccc1CNC(=O)c1ccc2c(CC[C@@H]3C[C@@](O)(CCC(F)(F)F)CC[C@@]23Cc2ccccc2)c1

InChI Key InChIKey=KCAXPRFNWUOBNC-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 140011   

TargetInterleukin-6(Human)
Pfizer

US Patent
LigandPNGBDBM140011(US8901310, Comparator A)
Affinity DataIC50: 36.4nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2015
Entry Details
Go to US Patent

LigandPNGBDBM140011(US8901310, Comparator A)
Affinity DataIC50: 1.00E+3nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2015
Entry Details
Go to US Patent

TargetGlucocorticoid receptor(Human)
Pfizer

US Patent
LigandPNGBDBM140011(US8901310, Comparator A)
Affinity DataIC50: 7.10nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2015
Entry Details
Go to US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM140011(US8901310, Comparator A)
Affinity DataEC50:  400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed