BDBM139658 US8894989, 37

SMILES O=c1[nH]nc2[nH]c(CN3Cc4ccccc4C3)nc3cccc1c23

InChI Key InChIKey=JLFSBHQQXIAQEC-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 139658   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 50nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 50nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 2nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mouse recombinant PARP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PARP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse recombinant PARP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 12nMpH: 8.0Assay Description:A convenient method to determine IC50 of a PARP inhibitor compound is a PARP assay using purified recombinant human PARP from Trevigan (Gaithersburg,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2015
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS1/TNKS2 (unknown origin) by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PARP1 by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant TNKS2 by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS1 by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human PARP1 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PARP2 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed