BDBM139549 US8889870, 9::US9388176, 9::US9820989, 9

SMILES CCc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1

InChI Key InChIKey=VHFZLHTWZZWIPV-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 139549   

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM139549(US8889870, 9 | US9388176, 9 | US9820989, 9)
Affinity DataIC50: 22nMpH: 7.4Assay Description:Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2015
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM139549(US8889870, 9 | US9388176, 9 | US9820989, 9)
Affinity DataIC50: 22nMpH: 7.4 T: 2°CAssay Description:Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM139549(US8889870, 9 | US9388176, 9 | US9820989, 9)
Affinity DataIC50: 52nMpH: 7.4 T: 2°CAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM139549(US8889870, 9 | US9388176, 9 | US9820989, 9)
Affinity DataKi:  22nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM139549(US8889870, 9 | US9388176, 9 | US9820989, 9)
Affinity DataKi:  52nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent