BDBM139295 US10858323, Compound 1::US8614223, 73

SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2)nc1

InChI Key InChIKey=LIIWIMDSZVNYHY-UHFFFAOYSA-N

Data  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 139295   

TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 94nMAssay Description:Inhibition of N-terminal GST-tagged HDAC1 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 128nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC2 expressed in baculovirus system using FTS as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 218nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC3 expressed in baculovirus system using FTS as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus system using FTS as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 94nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC1 expressed in baculovirus system using FTS as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 2nMAssay Description:Inhibition of heat inactivated recombinant human HDAC6 expressed in HEK293T cells assessed as inhibition of tau protein deacetylation incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 218nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 128nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 94nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal GST-tagged HDAC6 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 128nMAssay Description:Inhibition of N-terminal GST-tagged HDAC2 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 218nMAssay Description:Inhibition of N-terminal GST-tagged HDAC3 (unknown origin) expressed in baculovirus expression system using FTS as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 94nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2015
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal GST-tagged full-length human HDAC6 expressed in Sf9 infected baculovirus system using FTS as substrate preincubated for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 158nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 128nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 94nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 94nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2015
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 219nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2015
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM139295(US8614223, 73 | US10858323, Compound 1)
Affinity DataIC50: 128nMpH: 7.4 T: 2°CAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2015
Entry Details
Go to US Patent