BDBM13913 4-[(1-benzyl-1H-indazol-5-yl)amino]-5-ethyl-N-methylpyrrolo[1,2-a][1,2,4]triazine-6-carboxamide::CHEMBL197689::pyrrolo[2,1-f][1,2,4]triazine analog 7b

SMILES CCc1c(cn2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c12)C(=O)NC

InChI Key InChIKey=XSUGKVVBKGFATM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13913   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13913(4-[(1-benzyl-1H-indazol-5-yl)amino]-5-ethyl-N-meth...)
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against Sal2 (salivary gland carcinoma) cell line expressing active HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13913(4-[(1-benzyl-1H-indazol-5-yl)amino]-5-ethyl-N-meth...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against Sal2 (salivary gland carcinoma) cell line expressing active HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13913(4-[(1-benzyl-1H-indazol-5-yl)amino]-5-ethyl-N-meth...)
Affinity DataIC50: 130nMAssay Description:In vitro inhibitory concentration against HER2 cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13913(4-[(1-benzyl-1H-indazol-5-yl)amino]-5-ethyl-N-meth...)
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory concentration against EGFR cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed