BDBM13901 CHEMBL370934::ethyl 4-[(3-bromophenyl)amino]-5-ethylpyrrolo[1,2-a][1,2,4]triazine-6-carboxylate::pyrrolo[2,1-f][1,2,4]triazine analog 5b

SMILES CCOC(=O)c1cn2ncnc(Nc3cccc(Br)c3)c2c1CC

InChI Key InChIKey=ZCKGARDCKJFLRH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13901   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13901(ethyl 4-[(3-bromophenyl)amino]-5-ethylpyrrolo[1,2-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory concentration against Sal2 (salivary gland carcinoma) cell line expressing active HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13901(ethyl 4-[(3-bromophenyl)amino]-5-ethylpyrrolo[1,2-...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration against Sal2 (salivary gland carcinoma) cell line expressing active HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13901(ethyl 4-[(3-bromophenyl)amino]-5-ethylpyrrolo[1,2-...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibitory concentration against HER2 cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13901(ethyl 4-[(3-bromophenyl)amino]-5-ethylpyrrolo[1,2-...)
Affinity DataIC50: 60nMAssay Description:In vitro inhibitory concentration against EGFR cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed