BDBM138364 US10278929, Compound 12::US11337935, Compound 12::US8877795, 12

SMILES FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1

InChI Key InChIKey=NGJLOFCOEOHFKQ-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 138364   

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM138364(US8877795, 12 | US10278929, Compound 12 | US113379...)
Affinity DataIC50: 815nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetCDGSH iron-sulfur domain-containing protein 1(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM138364(US8877795, 12 | US10278929, Compound 12 | US113379...)
Affinity DataIC50: 6.94E+3nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM138364(US8877795, 12 | US10278929, Compound 12 | US113379...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant full length His-tagged PIM-1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2019
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM138364(US8877795, 12 | US10278929, Compound 12 | US113379...)
Affinity DataIC50: 815nMAssay Description:The FP assay was then adapted for HTS and used to screen a 120,000 member small molecule library for compounds that displaced the FP probe from the T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM138364(US8877795, 12 | US10278929, Compound 12 | US113379...)
Affinity DataIC50: 815nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent

TargetCDGSH iron-sulfur domain-containing protein 1(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM138364(US8877795, 12 | US10278929, Compound 12 | US113379...)
Affinity DataKi:  297nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed