BDBM138348 US8877944, 99

SMILES c1c(cc(c2c1CN(C2=O)C3CCN(CC3)C4CCC(CC4)(F)F)C(=O)N)F

InChI Key InChIKey=ARYVAQSYRLZVQD-UHFFFAOYSA-N

Data  61 IC50  6 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 67 hits for monomerid = 138348   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NIM1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd: <30nMAssay Description:Binding affinity to full length recombinant human PARP-1 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMaternal embryonic leucine zipper kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MELKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetEukaryotic elongation factor 2 kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EEF2KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDC7/DBF4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 40nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetIGF-like family receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NEK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  1.40E+3nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  9nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  1.39E+3nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-2 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human AUR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDGFRbMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase tousled-like 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ACK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BUB1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HaspinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EphA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 9.51E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
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