BDBM138210 US8871778, 189

SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1

InChI Key InChIKey=UTJDBKKZHLMLTN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 138210   

TargetTyrosine-protein kinase SYK(Human)
Genosco

US Patent
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 1nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Genosco

US Patent
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Genosco

US Patent
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 1nMT: 2°CAssay Description:Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Genosco

US Patent
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 44nMAssay Description:Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 7.34E+4nMT: 2°CAssay Description:Inhibition of purified full-length human ZAP70 pre-incubated for 30 mins at room temperature before UlighTM-PolyGT peptide substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 1.62E+5nMT: 2°CAssay Description:Inhibition of human JAK2 pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition by cell f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 478nMT: 2°CAssay Description:Inhibition of JAK3 (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM138210(US8871778, 189)
Affinity DataIC50: 9.59E+3nMT: 2°CAssay Description:Inhibition of human RET pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition by cell fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed