BDBM13770 2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymethyl)adamantan-2-yl]-2-methylpropanamide::adamantane ether 24

SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](CO)(C3)C2

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13770   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 2.50E+4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 6nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 8.91nMAssay Description:Inhibition of 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed