BDBM1377 3-{5-oxo-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]thiazol-9b-yl}benzonitrile::Thiazoloisoindol-5-one deriv. 21

SMILES O=C1N2CCSC2(c2ccccc12)c1cccc(c1)C#N

InChI Key InChIKey=FJVCNXDVCJZWRQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1377   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Boehringer Mannheim

LigandPNGBDBM1377(3-{5-oxo-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]thiazol...)
Affinity DataIC50: 1.81E+3nMpH: 7.7 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2004
Entry Details Article
PubMed