BDBM135936 US8859586, 20

SMILES COc1cc2CC(=O)N(C3CCC(CC3)C(=O)C3CCOCC3)[C@H](c3ccc(Cl)cc3)c2cc1OC(C)C

InChI Key InChIKey=ULFMQCWOJYGSHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 135936   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM135936(US8859586, 20)
Affinity DataIC50: 4.55E+3nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
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TargetProtein Mdm4(Human)
Novartis

US Patent
LigandPNGBDBM135936(US8859586, 20)
Affinity DataIC50: 3.48E+4nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
Go to US Patent