BDBM13549 3-(3,4,5-Trimethoxyphenyl)-N-(5-oxo-5-(2-(1,2,3,4-tetrahydroacridin-9-yl)hydrazino)-pentyl)propanamide::N-[4-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazinecarbonyl)butyl]-3-(3,4,5-trimethoxyphenyl)propanamide::tacrine derivative 16e

SMILES COc1cc(CCC(=O)NCCCCC(=O)NNc2c3CCCCc3nc3ccccc23)cc(OC)c1OC

InChI Key InChIKey=UZTWTDUISHKFGD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13549   

TargetAcetylcholinesterase(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13549(N-[4-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazineca...)
Affinity DataIC50: 59nMpH: 7.3 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCholinesterase(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13549(N-[4-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazineca...)
Affinity DataIC50: 0.139nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetAcetylcholinesterase(Pacific electric ray)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13549(N-[4-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazineca...)
Affinity DataIC50: 102nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13549(N-[4-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazineca...)
Affinity DataIC50: 54.7nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed