BDBM1354 9-Phenyl-2,3-Dihydrothiazola[2,3-a]isoindol-5(9bH)-one::9b-phenyl-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]thiazol-5-one::CHEMBL430623::Thiazoloisoindol-5-one deriv. 1

SMILES c1ccc(cc1)[C@]23c4ccccc4C(=O)N2CCS3

InChI Key InChIKey=CTGFADZNCCTVMP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 1354   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Boehringer Mannheim

LigandPNGBDBM1354(CHEMBL430623 | 9b-phenyl-2H,3H,5H,9bH-isoindolo[1,...)
Affinity DataIC50: 700nMpH: 7.7 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2004
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Boehringer Mannheim

Curated by ChEMBL
LigandPNGBDBM1354(CHEMBL430623 | 9b-phenyl-2H,3H,5H,9bH-isoindolo[1,...)
Affinity DataIC50: 280nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed