BDBM13538 3,4,5-Trimethoxy-N-(3-oxo-3-(2-(1,2,3,4-tetrahydroacridin-9-yl)hydrazino)propyl)-benzamide::3,4,5-trimethoxy-N-[2-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazinecarbonyl)ethyl]benzamide::tacrine derivative 15c

SMILES COc1cc(cc(OC)c1OC)C(=O)NCCC(=O)NNc1c2CCCCc2nc2ccccc12

InChI Key InChIKey=HHOZIIJUOGFCKO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13538   

TargetAcetylcholinesterase(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13538(3,4,5-trimethoxy-N-[2-(N'-1,2,3,4-tetrahydroacridi...)
Affinity DataIC50: 89.2nMpH: 7.3 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCholinesterase(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13538(3,4,5-trimethoxy-N-[2-(N'-1,2,3,4-tetrahydroacridi...)
Affinity DataIC50: 12.8nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetAcetylcholinesterase(Pacific electric ray)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13538(3,4,5-trimethoxy-N-[2-(N'-1,2,3,4-tetrahydroacridi...)
Affinity DataIC50: 49.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM13538(3,4,5-trimethoxy-N-[2-(N'-1,2,3,4-tetrahydroacridi...)
Affinity DataIC50: 100nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed