BDBM13523 1,4-diazepan-2-one 2c::4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-one::Diazepanone Analog 22

SMILES N[C@@H](CC(=O)N1CCCNC(=O)C1)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=NAFBUDKJGZAEGU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13523   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: 1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: 8.20E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: 142nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: 1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: 4.20E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2007
Entry Details Article
PubMed