BDBM134354 US8846658, 66

SMILES C[C@]1(CO[C@@](C(=N1)N)(C)C(F)(F)F)c2cccc(c2)NC(=O)c3ccc(cn3)Br

InChI Key InChIKey=YGNDEESWZOXXLA-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 134354   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 20nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain in presence of FRET substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 32nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of human cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM134354(US8846658, 66)
Affinity DataIC50: 32nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed