BDBM13397 4-({[4-amino-2-(3-methoxyphenyl)phenyl]methoxy}(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile::A313326 Analogue 34

SMILES COc1cccc(c1)-c1cc(N)ccc1COC(c1cncn1C)c1ccc(cc1)C#N

InChI Key InChIKey=NVTDTBWAXYAWGW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 13397   

TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13397(4-({[4-amino-2-(3-methoxyphenyl)phenyl]methoxy}(1-...)
Affinity DataIC50: 40nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bovine)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13397(4-({[4-amino-2-(3-methoxyphenyl)phenyl]methoxy}(1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
LigandPNGBDBM13397(4-({[4-amino-2-(3-methoxyphenyl)phenyl]methoxy}(1-...)
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of FTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed