BDBM13382 3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl}benzonitrile::A313326 Analogue 18::CHEMBL158553

SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N

InChI Key InChIKey=RGXWUSMPBUPQSB-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13382   

TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13382(CHEMBL158553 | 3-(3-chlorophenyl)-4-{[(4-cyanophen...)
Affinity DataIC50: 0.870nMpH: 7.0 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bovine)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13382(CHEMBL158553 | 3-(3-chlorophenyl)-4-{[(4-cyanophen...)
Affinity DataIC50: 1.30E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
LigandPNGBDBM13382(CHEMBL158553 | 3-(3-chlorophenyl)-4-{[(4-cyanophen...)
Affinity DataEC50:  5.20nMAssay Description:Reduced farnesylation of H-ras transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13382(CHEMBL158553 | 3-(3-chlorophenyl)-4-{[(4-cyanophen...)
Affinity DataIC50: 1.30nMAssay Description:inhibitory concentration needed to to reduce the bovine GGTase-catalyzed incorporation of [3H]-FPP into a biotin-linked K-ras (B) decapeptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13382(CHEMBL158553 | 3-(3-chlorophenyl)-4-{[(4-cyanophen...)
Affinity DataIC50: 871nMAssay Description:Inhibition of FTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed