BDBM13379 4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl}-3-phenylbenzonitrile::A313326 Analogue 15::CHEMBL127296

SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccccc1)C#N)c1ccc(cc1)C#N

InChI Key InChIKey=CXKCBVJOXUNDSU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13379   

TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13379(CHEMBL127296 | 4-{[(4-cyanophenyl)(1-methyl-1H-imi...)
Affinity DataIC50: 1.30nMpH: 7.0 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bovine)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13379(CHEMBL127296 | 4-{[(4-cyanophenyl)(1-methyl-1H-imi...)
Affinity DataIC50: 3.50E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
LigandPNGBDBM13379(CHEMBL127296 | 4-{[(4-cyanophenyl)(1-methyl-1H-imi...)
Affinity DataIC50: 3.50E+3nMAssay Description:In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]GGPP into biotinylated peptide corresponding to the C-term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13379(CHEMBL127296 | 4-{[(4-cyanophenyl)(1-methyl-1H-imi...)
Affinity DataIC50: 1.30nMAssay Description:In vitro inhibition of the human FTase-catalyzed incorporation of [3H]FPP into recombinant Ras CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13379(CHEMBL127296 | 4-{[(4-cyanophenyl)(1-methyl-1H-imi...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of FTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed