BDBM13376 4-({[4-chloro-2-(4-chlorophenyl)phenyl]methoxy}(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile::A313326 Analogue 9

SMILES Cn1cncc1C(OCc1ccc(Cl)cc1-c1ccc(Cl)cc1)c1ccc(cc1)C#N

InChI Key InChIKey=VFAFFWBKJDMJKB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 13376   

TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13376(4-({[4-chloro-2-(4-chlorophenyl)phenyl]methoxy}(1-...)
Affinity DataIC50: 4.80nMpH: 7.0 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bovine)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13376(4-({[4-chloro-2-(4-chlorophenyl)phenyl]methoxy}(1-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
LigandPNGBDBM13376(4-({[4-chloro-2-(4-chlorophenyl)phenyl]methoxy}(1-...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of FTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed