BDBM13281 4-Amino-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::4-amino-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 4a

SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2N)C(N)=N)C1=O

InChI Key InChIKey=BKODMNIABFWKMF-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 13281   

TargetCoagulation factor X(Human)
Rhone-Poulenc Rorer

LigandPNGBDBM13281(4-amino-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfo...)
Affinity DataKi:  6nM ΔG°:  -11.1kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Bovine)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13281(4-amino-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfo...)
Affinity DataKi:  6nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Rhone-Poulenc Rorer

LigandPNGBDBM13281(4-amino-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfo...)
Affinity DataKi:  299nM ΔG°:  -8.80kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed